French actress Sophie Semin started studying at the Université de Paris II and at the Institut Français de la Mode, before working for three years with Yohji Yamamoto. Between 1993 and 1995, she participated in the theater atelier of Blanche Salant and Paul Weaver, and then in the play Qu'une tranche de pain by Rainer Werner Fassbinder, at the Bastille Theater. She went on to perform in the play staged by Luc Bondy, Don Carlos de Verdi, and later in plays such as Stella de Goethe and Le Martyre de Saint Sébastien by Claudio Abbado and Claude Debussy. In cinema, she acted in the film Beyond The Clouds, directed by Michelangelo Antonioni and Wim Wenders, and in the Le Sacre du Printemps, inspired by the music of Stravinsky and directed by Olivier Hermann. Familiar with the work of Peter Handke, with whom she would marry years later, Semin was brought back on stage through Claus Peymann, who invited her into the play Le Voyage en Pirogue, presented at the Burgtheater in Vienna. Alongside Jean-Quentin Châtelain, Sophia Semin participated in the play Jusqu'à ce que le Jour Vous Sépare, also signed by Peter Handke and played the monologue of Krapp’s Last Tape, a play with only one act by Samuel Beckett. She returned to the cinema in 2016, to feature in a collaboration between Handke and Wim Wenders in the film Les beaux jours d'Aranjuez. In 2020, she appeared on stage in Handke´s new piece, presented at the Salzburg Festival, entitled Zdenek Adamec and named after the Czech student who in 2003 lit himself on fire on a public square.